Obsada:

• Bob Hoskins Eddie Valiant
• Christopher Lloyd Judge Doom
• Joanna Cassidy Dolores
• Charles Fleischer Roger Rabbit / Benny The Cab / Greasy / Psycho
• Stubby Kaye Marvin Acme
• Alan Tilvern R.K. Maroon
• Richard LeParmentier Lt. Santino
• Lou Hirsch Baby Herman
• Betsy Brantley Jessica's Performance Model
• Joel Silver Raoul
• Paul Springer Augie
• Richard Ridings Angelo
• Edwin Craig Arthritic Cowboy
• Lindsay Holiday Żołnierz
• Mike Edmonds Stretch
• Morgan Deare Editor / Gorilla
• Danny Capri Kid #1
• Christopher Hollosy Kid #2
• John-Paul Sipla Kid #3
• Laura Frances Blonde Starlet
• Joel Cutrara Forensic #1
• Billy J. Mitchell Forensic #2
• Eric B. Sindon Mailman
• Ed Herlihy Prezenter
• James O'Connell Conductor
• Eugene Guirterrez Teddy Valiant
• April Winchell Mrs. Herman
• Mae Questel Betty Boop
• Mel Blanc Daffy Duck / Tweety Bird / Bugs Bunny / Sylvester / Porky Pig
• Tony Anselmo Donald Duck
• Mary T. Radford Hippo
• Joe Alaskey Yosemite Sam / Foghorn Leghorn
• David L. Lander Smart Ass
• Fred Newman Stupid
• June Foray Wheezy / Toon Hag
• Russi Taylor Birds / Minnie Mouse
• Les Perkins Toad
• Richard Williams Droopy
• Wayne Allwine Mickey Mouse
• Pat Buttram Bullet #1
• Jim Cummings Bullet #2
• Jim Gallant Bullet #3
• Frank Sinatra Singing Sword
• Tony Pope Goofy / Wolf
• Peter Westy Pinocchio
• Cherry Davis Woody Woodpecker
• Amy Irving Jessica Rabbit
• Jack Angel Dodatkowe głosy
• Nancy Cartwright Dipped Shoe
• Christine Hewett Ink and Paint Club Patron
• Kit Hillier Ink and Paint Club Patron
• Derek Lyons Drunk in Bar
• Philip O'Brien Earl
• Ken Ralston Judge Doom when he runs away in Toontown
• Kathleen Turner Jessica Rabbit
• Frank Welker Dumbo / others