Obsada:

• Basil Rathbone Sherlock Holmes
• Nigel Bruce Dr. John H. Watson
• Hillary Brooke Lydia Marlowe
• Henry Daniell Professor Moriarty
• Paul Cavanagh Sir George Fenwick
• Matthew Boulton Inspector Gregson of Scotland Yard / Narrator
• Eve Amber Maude Fenwick
• Frederick Worlock Dr. Onslow
• Tom Bryson Corporal Williams
• Sally Shepherd Crandon, Marlowe's maid
• Mary Gordon Mrs. Hudson
• Eve Ashley Background woman
• John Burton Waring
• Harold De Becker Shoelace seller
• Leslie Denison Vincent
• Tony Ellis Carter
• Kay Harding Victim
• Alec Harford Commissioner of the CID
• Ivo Henderson Constable
• Tommy Hughes Newsman
• Colin Hunter Constable
• Olaf Hytten Norris, Fenwick's butler
• Boyd Irwin Short-tempered officer closing window
• Coulter Irwin Corporal Williams of the British Army
• Eric Mayne Member of Mesmer Club
• William H. O'Brien Pembrook House waiter
• Violet Seaton Nurse Mowbray
• Arthur Stenning Mesmer Club servant
• Percival Vivian Dr. Simnell