Obsada:

• Chris Rock Osmosis Jones
• Laurence Fishburne Thrax
• David Hyde Pierce Drix
• Brandy Norwood Leah
• William Shatner Mayor Phlegmming
• Ron Howard Tom Colonic
• Kid Rock Kidney Rock
• Kenny Olson Kidney Rock
• Jason Krause Kidney Rock
• Joe C. Kidney Rock
• Stefanie Eulinberg Kidney Rock
• Jimmie Bones Kidney Rock
• Uncle Kracker Kidney Rock
• Jonathan Adams Additional Character Voice
• Carlos Alazraqui Additional Character Voice
• Keith Anthony Additional Character Voice
• Eddie Barth Additional Character Voice
• Sally Ann Brooks Additional Character Voice
• Rodger Bumpass Additional Character Voice
• Michael Carven Additional Character Voice
• Paul Christie Additional Character Voice
• Janis Dardaris Additional Character Voice
• Wendy Dillon Additional Character Voice
• Antonio Fargas Additional Character Voice
• Eddie Frierson Additional Character Voice
• Donald Fullilove Additional Character Voice
• Jackie Gonneau Additional Character Voice
• Shannon Gregory Additional Character Voice
• Rif Hutton Additional Character Voice
• Richard Steven Horvitz Additional Character Voice
• Art Kimbro Additional Character Voice
• Joyce Kurtz Additional Character Voice
• Anne Lockhart Additional Character Voice
• Sherry Lynn Additional Character Voice
• Danny Mann Additional Character Voice
• Mickie McGowan Additional Character Voice
• John Melendez Additional Character Voice
• Héctor Mercado Additional Character Voice
• Paul Pape Additional Character Voice
• Marilyn Pasekoff Additional Character Voice
• Chris Phillips Additional Character Voice
• Lynne Redding Additional Character Voice
• Al Rodrigo Additional Character Voice
• Herschel Sparber Additional Character Voice
• Doug Stone Additional Character Voice
• Steve Susskind Additional Character Voice
• Keri Tombazian Additional Character Voice
• Paul Tuerpe Additional Character Voice
• Robert Wisdom Additional Character Voice
• Bill Murray Frank Detomello
• Molly Shannon Mrs. Boyd
• Chris Elliott Bob
• Elena Franklin Shane Detomello
• Danny Murphy Zookeeper Superintendent
• Jack McCullough Zookeeper
• Kathy Wege Mrs. Claris, Volcano Lady
• Will Dunn Oyster Boy
• Jackie Flynn School Janitor
• Kelsey Jordan Bus Girl #1
• Anna Byers Bus Girl #2
• Jesse Peter Laughing Boy
• John-Eliot Jordan Pea Soup Manager
• Nancy Byers Pea Soup Supervisor
• Kevin J. Flynn Docky's Clamshack Waiter
• Sean Gildea Dreamy Photographer
• Kathryn Frick Nurse #1
• Nicki Tyler Flynn Nurse #2
• Elizabeth Jordan Nurse #3
• Zen Gesner Emergency Room Doctor #1
• Marc Hyman Emergency Room Doctor #2
• Zak Penn Emergency Room Doctor #3
• Bob O'Brien The Zoo Visitors & Staff
• Tom Beachene The Zoo Visitors & Staff
• Diane Conrad The Zoo Visitors & Staff
• Judy Conrad The Zoo Visitors & Staff
• Bob Fennessy The Zoo Visitors & Staff
• John Britten The Zoo Visitors & Staff
• Katie Britten The Zoo Visitors & Staff
• Marlene Malone The Zoo Visitors & Staff
• Grady O'Connor The Zoo Visitors & Staff
• Barbara O'Connor The Zoo Visitors & Staff
• Jacqueline Wentzell The Zoo Visitors & Staff
• Morgan Wentzell The Zoo Visitors & Staff
• Jamie Heres The Zoo Visitors & Staff
• Jimmy Heres The Zoo Visitors & Staff
• Thomas Jordan The Zoo Visitors & Staff
• Ruth Meyer The Zoo Visitors & Staff
• Mandy Marsh The Zoo Visitors & Staff
• Tommy Barbieri The Zoo Visitors & Staff
• Allison Barbieri The Zoo Visitors & Staff
• Erica Johnson The Zoo Visitors & Staff
• Sydney J. Bartholomew Jr. The Zoo Visitors & Staff
• Bill Beauchene The Science Fair Contestants & Families
• Buzz Dunn The Science Fair Contestants & Families
• Laura Dunn The Science Fair Contestants & Families
• Krista-Jean Forand The Science Fair Contestants & Families
• Kena Flynn The Science Fair Contestants & Families
• Christina Kacmar The Science Fair Contestants & Families
• Diana O'Donnell The Science Fair Contestants & Families
• Dick Silva The Science Fair Contestants & Families
• Allison Kacmar The Science Fair Contestants & Families
• Nicole Brathwaite The Volcano Gal
• Emily O'Day The Volcano Gal
• Brianna Cabral The Volcano Gal
• Catherine Dunphy The Volcano Gal
• Chandler Vuilleumier The Volcano Gal
• Bill Wade Pea Soup Staff
• Bo Cleary Pea Soup Staff
• Bruce McIntyre Pea Soup Staff
• Colleen O'Donnell Docky's Clamshack
• Maryjane Foy Docky's Clamshack
• Jo Ann Nicewicz Docky's Clamshack
• Jillian Nicewicz Docky's Clamshack
• Docky Docky The Bikini Gang
• Heidi Hetzel The Bikini Gang
• Patricia Guiggey The Bikini Gang
• Rachael Kasner The Bikini Gang
• George Kouri The Bikini Gang
• Joe Murphy The Bikini Gang
• Dick Rubin The Bikini Gang
• Amy Suhay The Bikini Gang
• Brian Mone Oficer Policji
• Sean Fitzgerald Oficer Policji
• Beth Jordan The Emergency Room Nurse
• Mattie Ostiguy The Emergency Room Nurse
• Grace Costa The Emergency Room Nurse
• Maura O'Brien The Emergency Room Nurse
• Kathy Farrelly Pielęgniarka
• Shawn Fogarty Father at science fair
• Camden Munson
• Joel Silver Police Chief
• Ben Stein Doc
• Ben Urann Student
• Cortney Urichuck Student
• Megan Urichuck Student
• Jillian Wheeler Student