Obsada:

• Eddie Murphy Dr. John Dolittle
• Ossie Davis Archer Dolittle
• Oliver Platt Dr. Mark Weller
• Peter Boyle Calloway
• Richard Schiff Dr. Gene 'Geno' Reiss
• Kristen Wilson Lisa Dolittle
• Jeffrey Tambor Dr. Fish
• Kyla Pratt Maya Dolittle
• Raven-Symoné Raven-Symoné Charisse Dolittle
• Steven Gilborn Dr. Sam Litvack
• Erik Dellums Jeremy
• June Christopher Diane
• Cherie Franklin Mrs. Parkus
• Mark Adair-Rios Intern
• Don Calfa Patient at Hammersmith
• Arnold F. Turner Animal Control Officer
• Kay Yamamoto Receptionist
• Kellye Nakahara Beagle Woman
• Beth Grant Woman
• Yule Caise Vet's Assistant
• Brian Kwan Busboy
• L. Peter Callender Policeman
• Charles Branklyn Security Guard
• Cliff McLaughlin Mounted Policeman
• Richard Penn Mr. Galvin
• John Lafayette Reverend
• Raymond Matthew Mason 3-Year-Old John Dolittle
• Dari Gerard Smith 5-Year-Old John Dolittle
• Karl T. Wright Reporter
• Stan Sellers Cop #1
• Ming Lo Cop #2
• Norm MacDonald Lucky
• Albert Brooks Jacob the Tiger
• Chris Rock Rodney
• Reni Santoni Rat #1
• John Leguizamo Rat #2
• Julie Kavner Female Pigeon
• Garry Shandling Male Pigeon
• Ellen DeGeneres Prologue Dog
• Brian Doyle-Murray Old Beagle
• Phil Proctor Drunk Monkey
• Jenna Elfman Owl
• Gilbert Gottfried Compulsive Dog
• Phyllis Katz Goat
• Douglas Shamburger Pound Dog
• Jeff Doucette Possum
• Archie Hahn Heavy Woman's Dog
• Tom Towles German Shepherd
• Eddie Frierson Skunk
• Paul Reubens Raccoon
• Royce D. Applegate 'I Love You' Dog
• James F. Dean Orangutan
• Chad Einbinder Bettleheim the Cat
• Jonathan Lipnicki Baby Tiger
• Hamilton Camp Pig
• Kerrigan Mahan Penguin
• Paul Giamatti Blaine
• Kellan Patrick Jumping Boy
• Pruitt Taylor Vince Patient at Hammersmith